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Published mark

Upstream Bio, Inc.

NASDAQ: UPB. Canonical company identity and public leadership record.

US

Record source reportedRecord not claimedNo Eval published
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Alpha ID
alpha:company:48d41dd7-a948-47aa-bb24-2e857eff5000
SEC CIK
0002022626
Record version
vpublic-1:d751713988987e9331980363e24189ce:ro-d751713988987e9331980363e24189ce, published Oct 15, 2026
Newest evidence
Apr 16, 2026
Monitoring
Not yet monitored Details
Integrity
Not yet signed Methodology
CEO
E. Rand Sutherland, M.D.Chief Executive Officer
Chair
Not published
Independent
Not published5 directors published
Published claims
232 distinct sources
Evidence records
40 pinned
Source conflicts
0None open

Built from 2 distinct sources and 4 evidence records. Every Claim links to where it appears. Where nothing was published, the record states the coverage gap.

CorroboratedSource reportedAlpha inferenceNot disclosed

Public record. Alpha publishes governance facts about this organization from regulatory filings and company statements. Private enterprise overlay data is never projected here. The company can claim the record, correct, or dispute any Claim. How this works

DIRECTOR APPOINTED

Danielle Beckman seat on Upstream Bio, Inc., effective 2026-04-16.

EffectiveEffective Apr 16, 2026E2

Monitoring

Continuous

What the published record states about identity, evidence, evaluation, monitoring, authority, and freshness. Watched-source schedules are not published for this record.

  • Identityunclaimed
    Published
  • Evidencesource_reported
    Published
  • Evaluationnot_evaluated
    Published
  • MonitoringNot yet published for this record.
    Not published
  • AuthorityNot yet published for this record.
    Not published
  • Freshnesscurrent
    Published

Leadership

Evidence
RolePersonSinceStatusClaim
Chief Medical Officer and Head of Research and DevelopmentAaron Deykin, M.D.Not capturedunknownSource reportedE3
Chief Business OfficerAdam Houghton, Ph.D., M.B.A.Not capturedunknownSource reportedE3
Sr. Vice President, General Counsel and SecretaryAllison Ambrose, J.D.Not capturedunknownSource reportedE3
Chief Executive OfficerE. Rand Sutherland, M.D.Not capturedunknownSource reportedE3
Chief Financial and Operating OfficerMichael Paul Gray, M.B.A.Not capturedunknownSource reportedE3

Board of directors

Evidence

5 directors published. Independence determinations are not published for every director.

DirectorStatusSinceCommitteesClaim
Allison AmbroseIndependence not published2024None publishedSource reportedE2
Daniella BeckmanIndependence not published2024AUDIT COMMITTEE OF THE BOARD OF DIRECTORS OF UPSTREAM BIO, INC, chairSource reportedE2
Danielle BeckmanIndependence not published2026None publishedSource reportedE2
E. Rand SutherlandIndependence not published2024None publishedSource reportedE2
H. Edward Fleming, JrIndependence not published2023AUDIT COMMITTEE OF THE BOARD OF DIRECTORS OF UPSTREAM BIO, INCSource reportedE2
E. Rand Sutherland, M.D.Not independentNot publishedNone publishedSource reportedE3
Erez Chimovits, M.B.A., M.Sc.IndependentNot publishedNone publishedSource reportedE3
H. Edward Fleming, Jr., M.D.IndependentNot publishedNone publishedSource reportedE3
Liam Ratcliffe, M.B.Ch.B., Ph.D., M.B.A.IndependentNot publishedNone publishedSource reportedE3
Marcella Kuhlman Ruddy, M.D., M.S.IndependentNot publishedNone publishedSource reportedE3
Ronald C. Renaud, Jr., M.B.A.IndependentNot publishedNone publishedSource reportedE3

Committees and risk ownership

Evidence
CommitteeChairMembersRisks assigned
AUDIT COMMITTEE OF THE BOARD OF DIRECTORS OF UPSTREAM BIO, INCDaniella BeckmanDaniella Beckman, H. Edward Fleming, JrNot described in the published record
Committee RecordAUDIT COMMITTEE OF THE BOARD OF DIRECTORS OF UPSTREAM BIO, INC: Chair Daniella Beckman; Members Daniella Beckman (Chair); H. Edward Fleming, Jr
Source reportedE4
company:48d41dd7-a948-47aa-bb24-2e857eff5000:committee_record:21
Committee AppointmentDaniella Beckman: chair, AUDIT COMMITTEE OF THE BOARD OF DIRECTORS OF UPSTREAM BIO, INC
Source reportedE4
company:48d41dd7-a948-47aa-bb24-2e857eff5000:committee_appointment:22
Committee AppointmentH. Edward Fleming, Jr: member, AUDIT COMMITTEE OF THE BOARD OF DIRECTORS OF UPSTREAM BIO, INC
Source reportedE4
company:48d41dd7-a948-47aa-bb24-2e857eff5000:committee_appointment:23

Control and voting power

Evidence

No published claims

Nothing is published for this section yet. A missing Claim is a coverage state, not a negative finding.

Authority to act

Evidence and agent registry

Who can act for the company, and on whose authority. This is what a counterparty's agent checks before it accepts an order, signs, or pays.

Principal executive officerE. Rand Sutherland, M.D., Chief Executive Officer
Source reportedE3
company:48d41dd7-a948-47aa-bb24-2e857eff5000:leadership_role:19
Who can authorize an agentNot assessedNo Alpha inference about signing authority or board-reserved matters is published for this record.
Not assessed
bind
AI agents registered by the companyNot registered in the public RegistryAgent Deployments, Agent Use Cases, Authority Grants, TrustChecks, Action Ledger entries and Governance Receipts live in the private enterprise overlay. They are never projected into the public Registry without explicit cross-plane authorization. Absence here is a plane boundary, not evidence that the enterprise operates no agents.
Agent registry
agents
Delegations publishedNot disclosedBoard and officer delegation resolutions are not public filings and are not published in this record.
Search scope
delegations

Financials and market context

Evidence
Security ListingUPB (NASDAQ)
Source reportedE1
company:48d41dd7-a948-47aa-bb24-2e857eff5000:security_listing:24
Index membershipsNo current membership is published in Alpha's tracked index universe.This is not evidence that the company is absent from every market index.
None publishedAs of Oct 16, 2026. Rights-filtered public evidence only; no redistribution or model training is granted. Only source-backed memberships with an explicit public redistribution basis are returned.

Governance and policies

Evidence

No published claims

Nothing is published for this section yet. A missing Claim is a coverage state, not a negative finding.

Risk, audit, and cyber

Evidence

No published claims

Nothing is published for this section yet. A missing Claim is a coverage state, not a negative finding.

AI oversight and accountability

Evidence

No published claims

Nothing is published for this section yet. A missing Claim is a coverage state, not a negative finding.

Compensation

Evidence

No published claims

Nothing is published for this section yet. A missing Claim is a coverage state, not a negative finding.

Other published claims

Evidence

Published Claims that belong to no section above. Each keeps its permalink, evidence, and assertion state.

Legal NameUpstream Bio, Inc.
Source reportedE1
company:48d41dd7-a948-47aa-bb24-2e857eff5000:legal_name:1
Entity StatusPublic listing published
Source reportedE1
company:48d41dd7-a948-47aa-bb24-2e857eff5000:entity_status:3

Not yet in this record

Coverage

A gap is a coverage state, not a negative finding. These sections are expected for this entity class and are not yet published.

  • Corporate structureNot reviewed. Parent, subsidiary and predecessor structure explains who is governed.
  • OwnershipNot reviewed. Ownership and voting power determine who can influence the board.
  • FinancialsNot reviewed. Governance-relevant financial context frames capital and audit decisions.
  • CompensationNot reviewed. Pay design shows how incentives are governed.
  • GovernanceNot reviewed. Governing documents and provisions set the rules of the enterprise.
  • Shareholder governanceNot reviewed. Meeting and vote records show shareholder dissent and support.
  • AuditNot reviewed. Auditor, controls and restatements show assurance over reporting.
  • LegalNot reviewed. Material legal and regulatory matters show enforcement exposure.
  • RiskNot reviewed. Risk ownership links the board, committees, executives and controls.
  • CyberNot reviewed. Cyber and data governance is a disclosed oversight domain.
  • AI governanceNot reviewed. AI oversight is a differentiated Alpha governance domain.
  • Markets externalNot reviewed. Auditors, advisors, investors and regulators form the external ecosystem.
  • Absence of a leadership role, committee, or disclosure is not evidence that it does not exist.Absence of a leadership role, committee, or disclosure is not evidence that it does not exist.
  • Only explicitly published canonical company identity and current confirmed public roles are included.Only explicitly published canonical company identity and current confirmed public roles are included.
  • Absence of a board, committee, executive, listing, or claim is not evidence that it does not exist.Absence of a board, committee, executive, listing, or claim is not evidence that it does not exist.
  • Public retrieval does not grant redistribution, model-training, direct-contact, or relationship-pathfinding rights.Public retrieval does not grant redistribution, model-training, direct-contact, or relationship-pathfinding rights.
  • This Company Profile is an identity and evidence record, not an Alpha rating.This Company Profile is an identity and evidence record, not an Alpha rating.

Subject and corrections

Public-role doctrine

This record exists because the company is in the published Registry. The company can claim the record, correct, or dispute any Claim. Corrections are versioned and the original stays in history.

Basis
Published company record built from public sources
Sources
4 evidence records cited. 0 with redistribution rights.
Never published
Private enterprise overlay data: deployments, authority grants, TrustChecks, receipts, telemetry
Record claimed
No
Open disputes
0
Identity ownership
unclaimed
Claiming not yet available

If the company claims the record, its statements appear as their own assertion state and never overwrite the cited evidence.

Evidence

Authority and rights
  1. E1
    Alpha canonical company public projection
    Alpha canonical company public projection. canonical identity. Retrieved Oct 15, 2026. Cited by 4 Claims.
    Open web
    Rights not recorded, link only
    Evidence not pinned
  2. E2
    DEF 14A upb-20260416.htm
    sec proxy. Published Apr 16, 2026. Retrieved Sep 2, 2026. Cited by 5 Claims.
    Authoritative, regulatory filing
    Rights not recorded, link only
    Evidence not pinned
  3. E3
    SEC DEF 14A 0001193125-26-158966
    sec def 14a. Published Apr 16, 2026. Retrieved Sep 14, 2026. Cited by 11 Claims.
    Authoritative, regulatory filing
    Rights not recorded, link only
    Evidence not pinned
  4. E4
    AUDIT COMMITTEE OF THE BOARD OF DIRECTORS OF UPSTREAM BIO, INC
    governance_people_committees. sec proxy. Cited by 3 Claims.
    Authoritative, regulatory filing
    Rights not recorded, link only
    Evidence not pinned

What changed in version public-1:d751713988987e9331980363e24189ce:ro-d751713988987e9331980363e24189ce

vpublic-1:d751713988987e9331980363e24189ce:ro-d751713988987e9331980363e24189ce published Oct 15, 2026
  • Danielle Beckman seat on Upstream Bio, Inc., effective 2026-04-16.
  • Allison Ambrose seat on Upstream Bio, Inc., effective 2024-01-01.
  • Daniella Beckman seat on Upstream Bio, Inc., effective 2024-01-01.
  • E. Rand Sutherland seat on Upstream Bio, Inc., effective 2024-01-01.
  • H. Edward Fleming, Jr seat on Upstream Bio, Inc., effective 2023-01-01.
Appearance

Alpha Governance PBC. The Registry records reported facts and Alpha's assessments separately. A missing fact is not evidence that it is false.

Record alpha:company:48d41dd7-a948-47aa-bb24-2e857eff5000, version public-1:d751713988987e9331980363e24189ce:ro-d751713988987e9331980363e24189ce. https://registry.alpha.ac/companies/upstream-bio-inc

Navigate

On this record

  1. Overview
  2. Monitoring4
  3. Leadership5
  4. Board11
  5. Committees1
  6. Control and voting0
  7. Authority to act4
  8. Financials1
  9. Governance0
  10. Risk0
  11. AI oversight0
  12. Legal0
  13. Compensation0
  14. Other published claims3
  15. Coverage gaps17
  16. Linked people15
  17. Subject and corrections6
  18. Evidence4
  19. Version historyvpublic-1:d751713988987e9331980363e24189ce:ro-d751713988987e9331980363e24189ce

Linked records

Registry

Appearance

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  • Actions
    Switch to agent viewJSON, Markdown, MCP
  • Copy Alpha IDalpha:company:48d41dd7-a948-47aa-bb24-2e857eff5000
  • Cite this recordUpstream Bio, Inc.
  • Copy canonical URLregistry.alpha.ac/companies/upstream-bio-inc
  • Copy as MarkdownWith assertion states
  • Report an error
  • Theme: System
  • Theme: Light
  • Theme: Dark
  • Records
    Upstream Bio, Inc.Company
  • Aaron Deykin, M.D.Person
  • Adam Houghton, Ph.D., M.B.A.Person
  • Allison Ambrose, J.D.Person
  • E. Rand Sutherland, M.D.Person
  • Michael Paul Gray, M.B.A.Person
  • Allison AmbrosePerson
  • Daniella BeckmanPerson
  • Danielle BeckmanPerson
  • E. Rand SutherlandPerson
  • H. Edward Fleming, JrPerson
  • Erez Chimovits, M.B.A., M.Sc.Person
  • H. Edward Fleming, Jr., M.D.Person
  • Liam Ratcliffe, M.B.Ch.B., Ph.D., M.B.A.Person
  • Marcella Kuhlman Ruddy, M.D., M.S.Person
  • Ronald C. Renaud, Jr., M.B.A.Person
  • Sections
    OverviewUpstream Bio, Inc.
  • MonitoringUpstream Bio, Inc.
  • LeadershipUpstream Bio, Inc.
  • BoardUpstream Bio, Inc.
  • CommitteesUpstream Bio, Inc.
  • Control and votingUpstream Bio, Inc.
  • Authority to actUpstream Bio, Inc.
  • FinancialsUpstream Bio, Inc.
  • GovernanceUpstream Bio, Inc.
  • RiskUpstream Bio, Inc.
  • AI oversightUpstream Bio, Inc.
  • LegalUpstream Bio, Inc.
  • CompensationUpstream Bio, Inc.
  • Other published claimsUpstream Bio, Inc.
  • Coverage gapsUpstream Bio, Inc.
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Report an error

Reports attach to the Claim and go to an Alpha analyst through the correction form. Corrections are versioned, and the original stays in history.