# Upstream Bio, Inc. > Alpha governed public record. Unknown, unavailable, and unpublished values are never inferred as zero. ## Record | Field | Value | | --- | --- | | Representation | alpha-profile-markdown-v4 | | Protocol | Alpha Governance Facts Protocol 0.1 | | Schema | alpha.governance.entity.public.v1 | | Record version | public-1:d751713988987e9331980363e24189ce:ro-d751713988987e9331980363e24189ce | | Governance record representation | alpha-governance-record-v2 | | Canonical entity | alpha:company:48d41dd7-a948-47aa-bb24-2e857eff5000 | | Entity type | Company | | Canonical URL | https://registry.alpha.ac/companies/upstream-bio-inc | | Publication | PUBLISHED | | Verification | source_reported | | Verification schema | alpha-verification-states-v1 | | Ownership | unclaimed | | Published claims | 23 | | Claims under review | 1 | | Evidence records | 4 | | Conflicts | 0 | | Conflicts in internal review | 0 | | Observed | 2026-10-15T04:46:35.201169+00:00 | | Last reviewed | 2026-10-15T04:46:35.201169+00:00 | ## Identity - Legal name: Upstream Bio, Inc. - Display name: Upstream Bio, Inc. ## Alpha Governance Record | Field | Value | | --- | --- | | Governance Record schema | alpha-governance-record-v2 | | Ontology | alpha-governance-ontology-v1 | | Record version | public-1:d751713988987e9331980363e24189ce:ro-d751713988987e9331980363e24189ce | | As of | 2026-10-16T02:51:20.1723+00:00 | | Completeness | 0.409 | | Record Quality | 0.822 | | Directors | 11 | | Committees | 1 | | Governance events | 5 | | Entity class | public_company | ## Section coverage | Section | State | | --- | --- | | identity | PUBLISHED | | corporate_structure | NOT_REVIEWED | | board | PUBLISHED | | committees | PUBLISHED | | leadership | PUBLISHED | | ownership | NOT_REVIEWED | | financials | NOT_REVIEWED | | capital_structure | PUBLISHED | | compensation | NOT_REVIEWED | | governance | NOT_REVIEWED | | shareholder_governance | NOT_REVIEWED | | audit | NOT_REVIEWED | | legal | NOT_REVIEWED | | risk | NOT_REVIEWED | | cyber | NOT_REVIEWED | | ai_governance | NOT_REVIEWED | | agent_governance | RESTRICTED | | markets_external | NOT_REVIEWED | | events | PUBLISHED | | relationships | PUBLISHED | | assessments | PUBLISHED | | evidence | PUBLISHED | ## Board - Allison Ambrose: Director. Status: current. Independent: NOT_PUBLISHED. Since: 2024-01-01. claim_id=alpha:claim:company:48d41dd7-a948-47aa-bb24-2e857eff5000:leadership_role:5 - Daniella Beckman: Director. Status: current. Independent: NOT_PUBLISHED. Since: 2024-01-01. Committees: AUDIT COMMITTEE OF THE BOARD OF DIRECTORS OF UPSTREAM BIO, INC (chair). claim_id=alpha:claim:company:48d41dd7-a948-47aa-bb24-2e857eff5000:leadership_role:6 - Danielle Beckman: Director. Status: current. Independent: NOT_PUBLISHED. Since: 2026-04-16. claim_id=alpha:claim:company:48d41dd7-a948-47aa-bb24-2e857eff5000:leadership_role:7 - E. Rand Sutherland: Director. Status: current. Independent: NOT_PUBLISHED. Since: 2024-01-01. claim_id=alpha:claim:company:48d41dd7-a948-47aa-bb24-2e857eff5000:leadership_role:8 - H. Edward Fleming, Jr: Director. Status: current. Independent: NOT_PUBLISHED. Since: 2023-01-01. Committees: AUDIT COMMITTEE OF THE BOARD OF DIRECTORS OF UPSTREAM BIO, INC (member). claim_id=alpha:claim:company:48d41dd7-a948-47aa-bb24-2e857eff5000:leadership_role:11 - E. Rand Sutherland, M.D.: Chief Executive Officer and Director. Status: unknown. Independent: false. Since: NOT_PUBLISHED. claim_id=alpha:claim:company:48d41dd7-a948-47aa-bb24-2e857eff5000:leadership_role:9 - Erez Chimovits, M.B.A., M.Sc.: Director. Status: unknown. Independent: true. Since: NOT_PUBLISHED. claim_id=alpha:claim:company:48d41dd7-a948-47aa-bb24-2e857eff5000:leadership_role:10 - H. Edward Fleming, Jr., M.D.: Director. Status: unknown. Independent: true. Since: NOT_PUBLISHED. claim_id=alpha:claim:company:48d41dd7-a948-47aa-bb24-2e857eff5000:leadership_role:12 - Liam Ratcliffe, M.B.Ch.B., Ph.D., M.B.A.: Director. Status: unknown. Independent: true. Since: NOT_PUBLISHED. claim_id=alpha:claim:company:48d41dd7-a948-47aa-bb24-2e857eff5000:leadership_role:13 - Marcella Kuhlman Ruddy, M.D., M.S.: Director. Status: unknown. Independent: true. Since: NOT_PUBLISHED. claim_id=alpha:claim:company:48d41dd7-a948-47aa-bb24-2e857eff5000:leadership_role:14 - Ronald C. Renaud, Jr., M.B.A.: Director. Status: unknown. Independent: true. Since: NOT_PUBLISHED. claim_id=alpha:claim:company:48d41dd7-a948-47aa-bb24-2e857eff5000:leadership_role:15 ## Committees - AUDIT COMMITTEE OF THE BOARD OF DIRECTORS OF UPSTREAM BIO, INC (audit). Chair: Daniella Beckman. Members: Daniella Beckman (chair, current); H. Edward Fleming, Jr (member, current). committee_id=alpha:committee:upstream-bio-inc:audit-committee-of-the-board-of-directors-of-upstream-bio-inc ## Executive leadership - Aaron Deykin, M.D.: Chief Medical Officer and Head of Research and Development. Status: unknown. claim_id=alpha:claim:company:48d41dd7-a948-47aa-bb24-2e857eff5000:leadership_role:16 - Adam Houghton, Ph.D., M.B.A.: Chief Business Officer. Status: unknown. claim_id=alpha:claim:company:48d41dd7-a948-47aa-bb24-2e857eff5000:leadership_role:17 - Allison Ambrose, J.D.: Sr. Vice President, General Counsel and Secretary [GC]. Status: unknown. claim_id=alpha:claim:company:48d41dd7-a948-47aa-bb24-2e857eff5000:leadership_role:18 - E. Rand Sutherland, M.D.: Chief Executive Officer [CEO]. Status: unknown. claim_id=alpha:claim:company:48d41dd7-a948-47aa-bb24-2e857eff5000:leadership_role:19 - Michael Paul Gray, M.B.A.: Chief Financial and Operating Officer. Status: unknown. claim_id=alpha:claim:company:48d41dd7-a948-47aa-bb24-2e857eff5000:leadership_role:20 ## Governance events - DIRECTOR_APPOINTED: Danielle Beckman seat on Upstream Bio, Inc., effective 2026-04-16. Effective: 2026-04-16. Detected: 2026-10-15T04:46:35.201169+00:00. event_id=alpha:event:transition:dauzv61qe5tag - DIRECTOR_APPOINTED: Allison Ambrose seat on Upstream Bio, Inc., effective 2024-01-01. Effective: 2024-01-01. Detected: 2026-10-15T04:46:35.201169+00:00. event_id=alpha:event:transition:1fyf929i6sswj - DIRECTOR_APPOINTED: Daniella Beckman seat on Upstream Bio, Inc., effective 2024-01-01. Effective: 2024-01-01. Detected: 2026-10-15T04:46:35.201169+00:00. event_id=alpha:event:transition:7tt8hk1g02bmk - DIRECTOR_APPOINTED: E. Rand Sutherland seat on Upstream Bio, Inc., effective 2024-01-01. Effective: 2024-01-01. Detected: 2026-10-15T04:46:35.201169+00:00. event_id=alpha:event:transition:1k85tpyxp2gi2 - DIRECTOR_APPOINTED: H. Edward Fleming, Jr seat on Upstream Bio, Inc., effective 2023-01-01. Effective: 2023-01-01. Detected: 2026-10-15T04:46:35.201169+00:00. event_id=alpha:event:transition:143bs8pyzx7sd ## Scoped resources - `alpha://company/upstream-bio-inc` (contract): https://registry.alpha.ac/api/public/companies/upstream-bio-inc?format=record - `alpha://company/upstream-bio-inc/identity` (contract): https://registry.alpha.ac/api/public/companies/upstream-bio-inc?format=record§ion=identity - `alpha://company/upstream-bio-inc/corporate-structure` (contract): https://registry.alpha.ac/api/public/companies/upstream-bio-inc?format=record§ion=corporate-structure - `alpha://company/upstream-bio-inc/board` (contract): https://registry.alpha.ac/api/public/companies/upstream-bio-inc?format=record§ion=board - `alpha://company/upstream-bio-inc/committees` (contract): https://registry.alpha.ac/api/public/companies/upstream-bio-inc?format=record§ion=committees - `alpha://company/upstream-bio-inc/leadership` (contract): https://registry.alpha.ac/api/public/companies/upstream-bio-inc?format=record§ion=leadership - `alpha://company/upstream-bio-inc/ownership` (contract): https://registry.alpha.ac/api/public/companies/upstream-bio-inc?format=record§ion=ownership - `alpha://company/upstream-bio-inc/financials` (contract): https://registry.alpha.ac/api/public/companies/upstream-bio-inc?format=record§ion=financials - `alpha://company/upstream-bio-inc/capital-structure` (contract): https://registry.alpha.ac/api/public/companies/upstream-bio-inc?format=record§ion=capital-structure - `alpha://company/upstream-bio-inc/compensation` (contract): https://registry.alpha.ac/api/public/companies/upstream-bio-inc?format=record§ion=compensation - `alpha://company/upstream-bio-inc/governance` (contract): https://registry.alpha.ac/api/public/companies/upstream-bio-inc?format=record§ion=governance - `alpha://company/upstream-bio-inc/shareholder-governance` (contract): https://registry.alpha.ac/api/public/companies/upstream-bio-inc?format=record§ion=shareholder-governance - `alpha://company/upstream-bio-inc/audit` (contract): https://registry.alpha.ac/api/public/companies/upstream-bio-inc?format=record§ion=audit - `alpha://company/upstream-bio-inc/legal` (contract): https://registry.alpha.ac/api/public/companies/upstream-bio-inc?format=record§ion=legal - `alpha://company/upstream-bio-inc/risk` (contract): https://registry.alpha.ac/api/public/companies/upstream-bio-inc?format=record§ion=risk - `alpha://company/upstream-bio-inc/cyber` (contract): https://registry.alpha.ac/api/public/companies/upstream-bio-inc?format=record§ion=cyber - `alpha://company/upstream-bio-inc/ai-governance` (contract): https://registry.alpha.ac/api/public/companies/upstream-bio-inc?format=record§ion=ai-governance - `alpha://company/upstream-bio-inc/agents` (contract): https://registry.alpha.ac/api/public/companies/upstream-bio-inc?format=record§ion=agents - `alpha://company/upstream-bio-inc/ecosystem` (contract): https://registry.alpha.ac/api/public/companies/upstream-bio-inc?format=record§ion=ecosystem - `alpha://company/upstream-bio-inc/events` (contract): https://registry.alpha.ac/api/public/companies/upstream-bio-inc?format=record§ion=events - `alpha://company/upstream-bio-inc/relationships` (contract): https://registry.alpha.ac/api/public/companies/upstream-bio-inc?format=record§ion=relationships - `alpha://company/upstream-bio-inc/assessments` (contract): https://registry.alpha.ac/api/public/companies/upstream-bio-inc?format=record§ion=assessments - `alpha://company/upstream-bio-inc/evidence` (contract): https://registry.alpha.ac/api/public/companies/upstream-bio-inc?format=record§ion=evidence ## Role modules - NOT_ASSERTED ## Attention - NO_RECORDS_FOUND ## Committee data - Claim alpha:claim:company:48d41dd7-a948-47aa-bb24-2e857eff5000:committee_appointment:22: `{"kind":"committee_appointment","original_name":"AUDIT COMMITTEE OF THE BOARD OF DIRECTORS OF UPSTREAM BIO, INC","category":"audit","role":"chair","person":{"alpha_id":"alpha:person:daniella-beckman-upb","name":"Daniella Beckman"},"source_id":"governance_people_committees"}` - Claim alpha:claim:company:48d41dd7-a948-47aa-bb24-2e857eff5000:committee_appointment:23: `{"kind":"committee_appointment","original_name":"AUDIT COMMITTEE OF THE BOARD OF DIRECTORS OF UPSTREAM BIO, INC","category":"audit","role":"member","person":{"alpha_id":"alpha:person:h-edward-fleming-jr-upb","name":"H. Edward Fleming, Jr"},"source_id":"governance_people_committees"}` ## Leadership - Allison Ambrose: Director. Claim: alpha:claim:company:48d41dd7-a948-47aa-bb24-2e857eff5000:leadership_role:5. Valid from: 2024-01-01. Valid to: NOT_ASSERTED. Publication: PUBLISHED. Verification: source_reported. Assertion: source_reported. Evidence: alpha:projection-evidence:document:53250e56c2375c8a44d5c7ba14831e5c7a5aed0a708136575f7dd9182ffc9152. - Daniella Beckman: Director. Claim: alpha:claim:company:48d41dd7-a948-47aa-bb24-2e857eff5000:leadership_role:6. Valid from: 2024-01-01. Valid to: NOT_ASSERTED. Publication: PUBLISHED. Verification: source_reported. Assertion: source_reported. Evidence: alpha:projection-evidence:document:53250e56c2375c8a44d5c7ba14831e5c7a5aed0a708136575f7dd9182ffc9152. - Danielle Beckman: Director. Claim: alpha:claim:company:48d41dd7-a948-47aa-bb24-2e857eff5000:leadership_role:7. Valid from: 2026-04-16. Valid to: NOT_ASSERTED. Publication: PUBLISHED. Verification: source_reported. Assertion: source_reported. Evidence: alpha:projection-evidence:document:53250e56c2375c8a44d5c7ba14831e5c7a5aed0a708136575f7dd9182ffc9152. - E. Rand Sutherland: Director. Claim: alpha:claim:company:48d41dd7-a948-47aa-bb24-2e857eff5000:leadership_role:8. Valid from: 2024-01-01. Valid to: NOT_ASSERTED. Publication: PUBLISHED. Verification: source_reported. Assertion: source_reported. Evidence: alpha:projection-evidence:document:53250e56c2375c8a44d5c7ba14831e5c7a5aed0a708136575f7dd9182ffc9152. - E. Rand Sutherland, M.D.: Chief Executive Officer and Director. Claim: alpha:claim:company:48d41dd7-a948-47aa-bb24-2e857eff5000:leadership_role:9. Publication: PUBLISHED. Verification: source_reported. Assertion: source_reported. Evidence: alpha:projection-evidence:document:e6397173e8b5de838b991b00c6cd15ae2959903bc40fe8f245fd6479ca1d5c52. - Erez Chimovits, M.B.A., M.Sc.: Director. Claim: alpha:claim:company:48d41dd7-a948-47aa-bb24-2e857eff5000:leadership_role:10. Publication: PUBLISHED. Verification: source_reported. Assertion: source_reported. Evidence: alpha:projection-evidence:document:e6397173e8b5de838b991b00c6cd15ae2959903bc40fe8f245fd6479ca1d5c52. - H. Edward Fleming, Jr: Director. Claim: alpha:claim:company:48d41dd7-a948-47aa-bb24-2e857eff5000:leadership_role:11. Valid from: 2023-01-01. Valid to: NOT_ASSERTED. Publication: PUBLISHED. Verification: source_reported. Assertion: source_reported. Evidence: alpha:projection-evidence:document:53250e56c2375c8a44d5c7ba14831e5c7a5aed0a708136575f7dd9182ffc9152. - H. Edward Fleming, Jr., M.D.: Director. Claim: alpha:claim:company:48d41dd7-a948-47aa-bb24-2e857eff5000:leadership_role:12. Publication: PUBLISHED. Verification: source_reported. Assertion: source_reported. Evidence: alpha:projection-evidence:document:e6397173e8b5de838b991b00c6cd15ae2959903bc40fe8f245fd6479ca1d5c52. - Liam Ratcliffe, M.B.Ch.B., Ph.D., M.B.A.: Director. Claim: alpha:claim:company:48d41dd7-a948-47aa-bb24-2e857eff5000:leadership_role:13. Publication: PUBLISHED. Verification: source_reported. Assertion: source_reported. Evidence: alpha:projection-evidence:document:e6397173e8b5de838b991b00c6cd15ae2959903bc40fe8f245fd6479ca1d5c52. - Marcella Kuhlman Ruddy, M.D., M.S.: Director. Claim: alpha:claim:company:48d41dd7-a948-47aa-bb24-2e857eff5000:leadership_role:14. Publication: PUBLISHED. Verification: source_reported. Assertion: source_reported. Evidence: alpha:projection-evidence:document:e6397173e8b5de838b991b00c6cd15ae2959903bc40fe8f245fd6479ca1d5c52. - Ronald C. Renaud, Jr., M.B.A.: Director. Claim: alpha:claim:company:48d41dd7-a948-47aa-bb24-2e857eff5000:leadership_role:15. Publication: PUBLISHED. Verification: source_reported. Assertion: source_reported. Evidence: alpha:projection-evidence:document:e6397173e8b5de838b991b00c6cd15ae2959903bc40fe8f245fd6479ca1d5c52. - Aaron Deykin, M.D.: Chief Medical Officer and Head of Research and Development. Claim: alpha:claim:company:48d41dd7-a948-47aa-bb24-2e857eff5000:leadership_role:16. Publication: PUBLISHED. Verification: source_reported. Assertion: source_reported. Evidence: alpha:projection-evidence:document:e6397173e8b5de838b991b00c6cd15ae2959903bc40fe8f245fd6479ca1d5c52. - Adam Houghton, Ph.D., M.B.A.: Chief Business Officer. Claim: alpha:claim:company:48d41dd7-a948-47aa-bb24-2e857eff5000:leadership_role:17. Publication: PUBLISHED. Verification: source_reported. Assertion: source_reported. Evidence: alpha:projection-evidence:document:e6397173e8b5de838b991b00c6cd15ae2959903bc40fe8f245fd6479ca1d5c52. - Allison Ambrose, J.D.: Sr. Vice President, General Counsel and Secretary. Claim: alpha:claim:company:48d41dd7-a948-47aa-bb24-2e857eff5000:leadership_role:18. Publication: PUBLISHED. Verification: source_reported. Assertion: source_reported. Evidence: alpha:projection-evidence:document:e6397173e8b5de838b991b00c6cd15ae2959903bc40fe8f245fd6479ca1d5c52. - E. Rand Sutherland, M.D.: Chief Executive Officer. Claim: alpha:claim:company:48d41dd7-a948-47aa-bb24-2e857eff5000:leadership_role:19. Publication: PUBLISHED. Verification: source_reported. Assertion: source_reported. Evidence: alpha:projection-evidence:document:e6397173e8b5de838b991b00c6cd15ae2959903bc40fe8f245fd6479ca1d5c52. - Michael Paul Gray, M.B.A.: Chief Financial and Operating Officer. Claim: alpha:claim:company:48d41dd7-a948-47aa-bb24-2e857eff5000:leadership_role:20. Publication: PUBLISHED. Verification: source_reported. Assertion: source_reported. Evidence: alpha:projection-evidence:document:e6397173e8b5de838b991b00c6cd15ae2959903bc40fe8f245fd6479ca1d5c52. ## Roles - PUBLISHED ## Governance - NOT_ASSERTED ## Board committees - AUDIT COMMITTEE OF THE BOARD OF DIRECTORS OF UPSTREAM BIO, INC: Chair Daniella Beckman; Members Daniella Beckman (Chair); H. Edward Fleming, Jr. Claim: alpha:claim:company:48d41dd7-a948-47aa-bb24-2e857eff5000:committee_record:21. Publication: PUBLISHED. Verification: source_reported. Assertion: source_reported. Evidence: alpha:projection-evidence:16ae7b94a984c06a2a72eae8c633d3f9c442f1b9d26df1b325313129d8bb0492. ## Financials - NOT_ASSERTED ## Workforce - NOT_ASSERTED ## Market and index context - PUBLISHED ## Legal Name - Upstream Bio, Inc.. Claim: alpha:claim:company:48d41dd7-a948-47aa-bb24-2e857eff5000:legal_name:1. Publication: PUBLISHED. Verification: source_reported. Assertion: source_reported. Evidence: alpha:projection-evidence:174a97f4b9ef1fb52ce52a3a72598fe5424f9667b2882923a82e9490c81defa4. ## Entity Status - Public listing published. Claim: alpha:claim:company:48d41dd7-a948-47aa-bb24-2e857eff5000:entity_status:3. Publication: PUBLISHED. Verification: source_reported. Assertion: source_reported. Evidence: alpha:projection-evidence:174a97f4b9ef1fb52ce52a3a72598fe5424f9667b2882923a82e9490c81defa4. ## Published Fact - US. Claim: alpha:claim:company:48d41dd7-a948-47aa-bb24-2e857eff5000:published_fact:4. Publication: PUBLISHED. Verification: source_reported. Assertion: source_reported. Evidence: alpha:projection-evidence:174a97f4b9ef1fb52ce52a3a72598fe5424f9667b2882923a82e9490c81defa4. ## Committee Appointment - Daniella Beckman: chair, AUDIT COMMITTEE OF THE BOARD OF DIRECTORS OF UPSTREAM BIO, INC. Claim: alpha:claim:company:48d41dd7-a948-47aa-bb24-2e857eff5000:committee_appointment:22. Publication: PUBLISHED. Verification: source_reported. Assertion: source_reported. Evidence: alpha:projection-evidence:16ae7b94a984c06a2a72eae8c633d3f9c442f1b9d26df1b325313129d8bb0492. - H. Edward Fleming, Jr: member, AUDIT COMMITTEE OF THE BOARD OF DIRECTORS OF UPSTREAM BIO, INC. Claim: alpha:claim:company:48d41dd7-a948-47aa-bb24-2e857eff5000:committee_appointment:23. Publication: PUBLISHED. Verification: source_reported. Assertion: source_reported. Evidence: alpha:projection-evidence:16ae7b94a984c06a2a72eae8c633d3f9c442f1b9d26df1b325313129d8bb0492. ## Security Listing - UPB (NASDAQ). Claim: alpha:claim:company:48d41dd7-a948-47aa-bb24-2e857eff5000:security_listing:24. Publication: PUBLISHED. Verification: source_reported. Assertion: source_reported. Evidence: alpha:projection-evidence:174a97f4b9ef1fb52ce52a3a72598fe5424f9667b2882923a82e9490c81defa4. ## Coverage states | Field | Value | | --- | --- | | Identity | PUBLISHED | | Business | PUBLISHED | | Leadership | PUBLISHED | | Board and committees | PUBLISHED | | Governance | NOT_ASSERTED | | Financials | NOT_ASSERTED | | Workforce | NOT_ASSERTED | | Ownership | NOT_ASSERTED | | Ratings | NOT_PUBLISHED | | Market and index context | PUBLISHED | ## Public sources - alpha:projection-evidence:174a97f4b9ef1fb52ce52a3a72598fe5424f9667b2882923a82e9490c81defa4: [Alpha canonical company public projection](https://www.alpha.ac/api/public/companies/upstream-bio-inc). - alpha:projection-evidence:document:53250e56c2375c8a44d5c7ba14831e5c7a5aed0a708136575f7dd9182ffc9152: [DEF 14A upb-20260416.htm](https://www.sec.gov/Archives/edgar/data/2022626/000119312526158966/upb-20260416.htm). - alpha:projection-evidence:document:e6397173e8b5de838b991b00c6cd15ae2959903bc40fe8f245fd6479ca1d5c52: [SEC DEF 14A 0001193125-26-158966](https://www.sec.gov/Archives/edgar/data/2022626/000119312526158966/upb-20260416.htm). - alpha:projection-evidence:16ae7b94a984c06a2a72eae8c633d3f9c442f1b9d26df1b325313129d8bb0492: [AUDIT COMMITTEE OF THE BOARD OF DIRECTORS OF UPSTREAM BIO, INC](https://www.sec.gov/Archives/edgar/data/2022626/000119312526158966/upb-20260416.htm). ## Rights | Field | Value | | --- | --- | | public_retrieval | allowed | | agent_retrieval | allowed | | redistribution | not_granted | | model_training | not_granted | | commercial_use | not_specified | | relationship_pathfinding | not_granted | | direct_contact | not_granted | ## Limitations - Absence of a leadership role, committee, or disclosure is not evidence that it does not exist. - Only explicitly published canonical company identity and current confirmed public roles are included. - Absence of a board, committee, executive, listing, or claim is not evidence that it does not exist. - Public retrieval does not grant redistribution, model-training, direct-contact, or relationship-pathfinding rights. - This Company Profile is an identity and evidence record, not an Alpha rating. ## Alternate representations - [Canonical profile](https://registry.alpha.ac/companies/upstream-bio-inc) - [Public Markdown](https://registry.alpha.ac/companies/upstream-bio-inc.md) - [Public JSON](https://registry.alpha.ac/api/public/companies/upstream-bio-inc?format=record) - [JSON-LD](https://registry.alpha.ac/api/public/companies/upstream-bio-inc?format=jsonld) - MCP resource: `alpha://companies/upstream-bio-inc` at https://mcp.alpha.ac/mcp ## Connected governance records Only explicitly published, rights-cleared records. Missing records do not establish absence, safety, or complete coverage. ## Critical-risk oversight Snapshot as of 2026-10-16T02:51:19.973361+00:00; recorded 2026-10-16T02:51:19.973361+00:00. Every published assignment for this snapshot is listed. Only explicitly reviewed, rights-cleared assignments in effect on the as-of date, in the company's own wording. An assignment shows where oversight is placed, not whether it is effective. Missing records do not establish absence.